Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Aug 17;376(6541):572-5.
doi: 10.1038/376572a0.

Modulation of memory fields by dopamine D1 receptors in prefrontal cortex

G V Williams  1 , P S Goldman-Rakic
Affiliations

Modulation of memory fields by dopamine D1 receptors in prefrontal cortex

G V Williams et al. Nature. .

Abstract

Dopamine has been implicated in the cognitive process of working memory but the cellular basis of its action has yet to be revealed. By combining iontophoretic analysis of dopamine receptors with single-cell recording during behaviour, we found that D1 antagonists can selectively potentiate the 'memory fields' of prefrontal neurons which subserve working memory. The precision shown for D1 receptor modulation of mnemonic processing indicates a direct gating of selective excitatory synaptic inputs to prefrontal neurons during cognition.

PubMed Disclaimer

Comment in

Publication types

Substances