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. 1995 Aug;222(2):146-54.
doi: 10.1097/00000658-199508000-00006.

Exogenous transforming growth factor-beta amplifies its own expression and induces scar formation in a model of human fetal skin repair

R Y Lin  1 , K M Sullivan, P A Argenta, M Meuli, H P Lorenz, N S Adzick
Affiliations

Exogenous transforming growth factor-beta amplifies its own expression and induces scar formation in a model of human fetal skin repair

R Y Lin et al. Ann Surg. 1995 Aug.

Abstract

Objective: Fetal skin wounds heal without scarring. To determine the role of TGF-beta 1 in fetal wound healing, mRNA expression of TGF-beta 1 was analyzed in human fetal and adult skin wounds.

Methods: Human fetal skin transplanted to a subcutaneous location on an adult athymic mouse that was subsequently wounded heals without scar, whereas human adult skin heals with scar formation in that location. In situ hybridization for TGF-beta 1 mRNA expression and species-specific immunohistochemistry for fibroblasts, macrophages, and neutrophils were performed in human adult wounds, fetal wounds, and fetal wounds treated with a TGF-beta 1 slow release disk.

Results: Transforming growth factor-beta 1 mRNA expression was induced by wounding adult skin. No TGF-beta 1 mRNA upregulation was detected in human fetal skin after wounding. However, when exogenous TGF-beta 1 was added to human fetal skin, induction of TGF-beta 1 mRNA expression in human fetal fibroblasts occurred, an adult-like inflammatory response was detected, and the skin healed with scar formation.

Conclusions: Transforming growth factor-beta 1 is an important modulator in scar formation. Anti-TGF-beta 1 strategies may promote scarless healing in adult wounds.

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References

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