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Review
. 1995 May;19(5):373-88.
doi: 10.1006/cbir.1995.1083.

Transforming growth factor alpha

V Kumar  1 , S A Bustin, I A McKay
Affiliations
Review

Transforming growth factor alpha

V Kumar et al. Cell Biol Int. 1995 May.

Abstract

Transforming growth factor alpha (TGF alpha) is a close relative of epidermal growth factor (EGF), the first polypeptide mitogen discovered in 1962 (Cohen, 1962). TGF alpha, like EGF, exerts its effect on cells through binding to the EGF-Receptor (EGF-R). Here we review the molecular and cell biology of TGF alpha before proceeding to describe our own work on signaling molecules induced in response to activation of the EGF-R.

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