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. 1995 Sep;63(9):3697-701.
doi: 10.1128/iai.63.9.3697-3701.1995.

Decomplementation by cobra venom factor suppresses Yersinia-induced arthritis in rats

K I Gaede  1 , E Baumeister, J Heesemann
Affiliations

Decomplementation by cobra venom factor suppresses Yersinia-induced arthritis in rats

K I Gaede et al. Infect Immun. 1995 Sep.

Abstract

Lewis rats experimentally infected with Yersinia enterocolitica O8 develop Yersinia-induced arthritis (YIA), which resembles very much reactive arthritis in humans. To investigate the involvement of serum complement in induction and maintenance of YIA, we decomplementated Yersinia-infected Lewis rats by treatment with cobra venom factor starting on day 7 after infection (prearthritic state). Reduction of serum complement activity in vivo by cobra venom factor treatment coincided with suppression of YIA clinically and histomorphologically.

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