Thyroid antibodies are not a risk factor for pregnancies with Down syndrome
- PMID: 7644435
- DOI: 10.1002/pd.1970150508
Thyroid antibodies are not a risk factor for pregnancies with Down syndrome
Abstract
The observation that thyroid disease is frequent in mothers of children with Down syndrome (DS) has suggested that maternal thyroid antibodies could be a factor predisposing to trisomy 21 in their offspring. In this study, the incidences of thyroglobulin (Tg) and thyroid peroxidase (TPO) antibodies were analysed with a sensitive solid-phase immunosorbent radioassay in sera from 29 mothers giving birth to children with trisomy 21 and 87 control mothers. The serum samples were collected at delivery. There was no statistical difference regarding the proportion of thyroid antibodies (against Tg and/or TPO) in the two groups. Thyroid antibodies were detected in 6/29 (20.7 per cent) of the DS mothers and in 23/87 (26.4 per cent) of the control mothers. Among the women with thyroid antibodies, 4/6 (66.7 per cent) of the DS mothers and 12/23 (52 per cent) of the control mothers had antibodies against both Tg and TPO. There was no increase in the relative risk of having a child with DS if the titre of either Tg or TPO antibodies or both were positive, i.e. > or = 1/5. The results indicate that the presence of thyroid antibodies in the serum of a pregnant women has no prognostic value for the birth of an infant with DS.
Similar articles
-
Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study.J Clin Endocrinol Metab. 2009 Mar;94(3):772-9. doi: 10.1210/jc.2008-1520. Epub 2008 Dec 23. J Clin Endocrinol Metab. 2009. PMID: 19106271
-
Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency.Clin Endocrinol (Oxf). 2003 Jan;58(1):36-42. doi: 10.1046/j.1365-2265.2003.01633.x. Clin Endocrinol (Oxf). 2003. PMID: 12519410
-
Significance of thyroglobulin antibodies cross-reactive with thyroperoxidase (TGPO antibodies) in individual patients and immunized mice.Clin Exp Immunol. 1993 Apr;92(1):65-72. doi: 10.1111/j.1365-2249.1993.tb05949.x. Clin Exp Immunol. 1993. PMID: 8467565 Free PMC article.
-
Thyroid antibodies and risk of preterm delivery: a meta-analysis of prospective cohort studies.Eur J Endocrinol. 2012 Oct;167(4):455-64. doi: 10.1530/EJE-12-0379. Epub 2012 Jul 23. Eur J Endocrinol. 2012. PMID: 22826476 Review.
-
Thyroid peroxidase autoantibodies in euthyroid subjects.Best Pract Res Clin Endocrinol Metab. 2005 Mar;19(1):1-15. doi: 10.1016/j.beem.2004.11.003. Best Pract Res Clin Endocrinol Metab. 2005. PMID: 15826919 Review.
Cited by
-
Investigation of a cluster of children with Down's syndrome born to mothers who had attended a school in Dundalk, Ireland.Occup Environ Med. 2000 Dec;57(12):793-804. doi: 10.1136/oem.57.12.793. Occup Environ Med. 2000. PMID: 11077007 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous