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. 1995 Aug 15;92(17):7869-73.
doi: 10.1073/pnas.92.17.7869.

Frequency encoding in excitable systems with applications to calcium oscillations

Y Tang  1 , H G Othmer
Affiliations

Frequency encoding in excitable systems with applications to calcium oscillations

Y Tang et al. Proc Natl Acad Sci U S A. .

Abstract

A number of excitable cell types respond to a constant hormonal stimulus with a periodic oscillation in intracellular calcium. The frequency of oscillation is often proportional to the hormonal stimulus, and one says that the stimulus is frequency encoded. Here we develop a theory of frequency encoding in excitable systems and apply it to intracellular calcium oscillations that results from increases in the intracellular level of inositol 1,4,5-triphosphate.

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