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Comparative Study
. 1995 Aug 15;92(17):8011-5.
doi: 10.1073/pnas.92.17.8011.

An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding

M A Stamnes  1 , M W Craighead, M H Hoe, N Lampen, S Geromanos, P Tempst, J E Rothman
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Comparative Study

An integral membrane component of coatomer-coated transport vesicles defines a family of proteins involved in budding

M A Stamnes et al. Proc Natl Acad Sci U S A. .

Erratum in

  • Proc Natl Acad Sci U S A 1995 Nov 7;92(23):10816

Abstract

We have isolated a major integral membrane protein from Golgi-derived coatomer-coated vesicles. This 24-kDa protein, p24, defines a family of integral membrane proteins with homologs present in yeast and humans. In addition to sequence similarity, all p24 family members contain a motif with the characteristic heptad repeats found in coiled coils. When the yeast p24 isoform, yp24A, is knocked out in a strain defective for vesicle fusion, a dramatic reduction in the accumulation of transport vesicles is observed. Together, these results indicate a role for this protein family in the budding of coatamer-coated and other species of coated vesicles.

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