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Review
. 1995 Mar;65(3):291-302.
doi: 10.1016/0163-7258(95)98595-h.

Interleukin-1 in the treatment of cancer

B D Curti  1 , J W Smith 2nd
Affiliations
Review

Interleukin-1 in the treatment of cancer

B D Curti et al. Pharmacol Ther. 1995 Mar.

Abstract

Interleukin-1 (IL-1) is a cytokine with many activities central to immune function and hematopoiesis. Many IL-1 properties can be potentially exploited in the treatment of malignancy. This review describes the toxicities and antitumor effects observed in Phase I and II trials of IL-1 in cancer patients. The immunophysiology and the induction of cytokines by IL-1 has been examined in many of the Phase I trials and has aided in understanding IL-1 effects in humans. The influence of IL-1 on granulopoiesis and thrombopoiesis when given by different regimes is also reviewed in detail.

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