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Clinical Trial
. 1994 Oct;62(4):708-10.
doi: 10.1016/s0015-0282(16)56992-1.

Human chorionic gonadotropin supplementation in recurring pregnancy loss: a controlled trial

S Quenby  1 , R G Farquharson
Affiliations
Free article
Clinical Trial

Human chorionic gonadotropin supplementation in recurring pregnancy loss: a controlled trial

S Quenby et al. Fertil Steril. 1994 Oct.
Free article

Abstract

Objectives: To investigate the efficacy of hCG in the management of recurrent early pregnancy loss.

Design: A prospective, randomized, controlled trial.

Setting: Miscarriage Clinic, Women's Hospital, Liverpool, United Kingdom.

Subjects: Eighty-one women attending the miscarriage clinic with idiopathic recurrent pregnancy loss were randomized to receive hCG supplementation or placebo in early pregnancy.

Main outcome measure: The success rate or live birth rate.

Results: In women with regular menstrual cycles it was found that hCG had no beneficial effect, the pregnancy success rate being 86% in both groups. However, women with oligomenorrhea had a pregnancy success rate of 40% in the placebo group but a statistically significant improvement to 86% if hCG was given.

Conclusions: Human chorionic gonadotropin can be recommended for idiopathic recurrent pregnancy loss in women with oligomenorrhea.

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