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Case Reports
. 1994 Dec;6(4):255-8.
doi: 10.3109/10401239409149012.

Bupropion/nortriptyline combination for refractory depression

J T Apter  1 , S F Kushner, R L Woolfolk
Affiliations
Case Reports

Bupropion/nortriptyline combination for refractory depression

J T Apter et al. Ann Clin Psychiatry. 1994 Dec.

Abstract

Many patients fail to respond to one or more trials with a single antidepressant. In such cases polypharmacy is often necessary and beneficial, although there may be an increased risk of complications. Four case reports are presented of patients with refractory depression treated successfully with the combination of the tricyclic antidepressant nortriptyline and the newer agent bupropion.

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