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. 1995 May;115(1):1-2.
doi: 10.1111/j.1476-5381.1995.tb16310.x.

Effect of a 5-HT1 receptor agonist, CP-122,288, on oedema formation induced by stimulation of the rat saphenous nerve

R Kajekar  1 , P Gupta, N B Shepperson, S D Brain
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Effect of a 5-HT1 receptor agonist, CP-122,288, on oedema formation induced by stimulation of the rat saphenous nerve

R Kajekar et al. Br J Pharmacol. 1995 May.

Abstract

Neurogenic oedema formation in the rat hind paw skin induced by electrical stimulation of the saphenous nerve and measured by extravasation of [125I]-albumin, was inhibited by the 5-HT1B receptor agonist, CP-93,129, and the novel tryptamine analogue, CP-122,288. Significant inhibition of up to 66% of control was observed with CP-122,288 (2 x 10(-14) - 2 x 10(-7) mol kg-1) and CP-93,129 (5 x 10(-7) - 5 x 10(-6) mol kg-1), with the minimum effective dose for CP-122,288 being about 10(7) fold less than that for CP-93,129. Oedema formation induced by the intradermal administration of exogenous mediators (substance P and histamine) in rat dorsal skin was not inhibited by CP-122,288 (2 x 10(-10) mol kg-1). These results suggest that CP-122,288 is a potent inhibitor of neurogenic inflammation in rat skin and that the effect may be due to a prejunctional inhibition of neuropeptide release.

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References

    1. Br J Pharmacol. 1991 Sep;104(1):3-4 - PubMed
    1. Trends Pharmacol Sci. 1992 Aug;13(8):307-11 - PubMed
    1. Br J Pharmacol. 1993 Oct;110(2):772-6 - PubMed
    1. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10208-12 - PubMed
    1. Naunyn Schmiedebergs Arch Pharmacol. 1979 Dec;310(2):175-83 - PubMed

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