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. 1975 Aug;32(2):193-8.
doi: 10.1038/bjc.1975.149.

Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan

J L Millar, B N Hudspith, N M Blackett
Free PMC article

Reduced lethality in mice receiving a combined dose of cyclophosphamide and busulphan

J L Millar et al. Br J Cancer. 1975 Aug.
Free PMC article

Abstract

Animals treated with a sufficiently high dose of busulphan die about 14 days later from bone marrow failure. A single, appropriately timed injection of cyclophosphamide can save these mice. The nature of this protection is shown to be the cyclophosphamide induced elaboration of a humoral factor which stimulates haemopoietic recovery.

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References

    1. Radiat Res. 1968 Dec;36(3):521-7 - PubMed
    1. N Engl J Med. 1972 Feb 3;286(5):227-32 - PubMed
    1. Blood. 1971 Feb;37(2):196-203 - PubMed
    1. Blood. 1971 Nov;38(5):559-68 - PubMed
    1. Chem Biol Interact. 1970 Dec;2(4):273-80 - PubMed