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. 1995 Aug 7;369(2-3):326-30.
doi: 10.1016/0014-5793(95)00777-7.

Molecular cloning and sequence analysis of human preprocathepsin C

A Paris  1 , B Strukelj, J Pungercar, M Renko, I Dolenc, V Turk
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Free article

Molecular cloning and sequence analysis of human preprocathepsin C

A Paris et al. FEBS Lett. .
Free article

Abstract

A cDNA clone (C1) coding for human preprocathepsin C was isolated from a human ileum cDNA library using a rat kidney-derived RT-PCR probe and its complete nucleotide sequence determined. The full-length 1857 bp sequence codes for a protein of 463 amino acid residues with a calculated molecular mass of 51848 Da. Comparison of the deduced amino acid sequence with that of rat preprocathepsin C indicates an 87.5% identity. A multiple alignment of the deduced cathepsin C sequence of 233 residues which, by analogy to other cystein proteinases, corresponds to the mature protein, confirms that human cathepsin C belongs to the papain superfamily.

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