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Clinical Trial
. 1976 Feb 7;1(6005):318-21.
doi: 10.1136/bmj.1.6005.318.

Metronidazole in prevention and treatment of bacteroides infections after appendicectomy

A T Willis, I R Ferguson, P H Jones, K D Phillips, P V Tearle, R B Berry, R V Fiddian, D F Graham, D H Harland, D B Innes, W M Mee, R L Rothwell-Jackson, I Sutch, C Kilbey, D Edwards
Clinical Trial

Metronidazole in prevention and treatment of bacteroides infections after appendicectomy

A T Willis et al. Br Med J. .

Abstract

The frequency of non-clostridial anaerobic infection was studied in 95 patients who had undergone acute appendicectomy: 49 received prophylactic metronidazole and 46 received placebo. Anaerobic infection did not develop in any of the metronidazole-treated patients, but infections did develop in nine (19%) of the 46 controls. Metronidazole is conveniently administered by suppository to patients who cannot take oral drugs. Five patients with intra-abdominal infections caused by non-clostridial anaerobes were successfully treated with metronidazole.

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References

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