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. 1995 Sep 1;182(3):811-20.
doi: 10.1084/jem.182.3.811.

Involvement of p59fynT in interleukin-5 receptor signaling

M W Appleby  1 , J D Kerner, S Chien, C R Maliszewski, S Bondada, R M Perlmutter, S ] Bondadaa S [corrected to Bondada
Affiliations

Involvement of p59fynT in interleukin-5 receptor signaling

M W Appleby et al. J Exp Med. .

Erratum in

  • J Exp Med 1995 Oct 1;182(4):1179

Abstract

Previous studies implicate the nonreceptor protein tyrosine kinase (PTK) p59fyn in the propagation of signals from the B cell antigen receptor. To elucidate the functions of this kinase, we examined B cell responsiveness in mice engineered to lack the hematopoietic isoform of p59fyn. Remarkably, antigen receptor signaling was only modestly defective in fynTnull B cells. In contrast, signaling from the interleukin (IL)-5 receptor which ordinarily provides a comitogenic stimulus with antiimmunoglobulin, was completely blocked. Our results document the importance of p59fynT in IL-5 responses in B cells, and they support a general model for cytokine receptor signal transduction involving the simultaneous recruitment of at least three families of PTK.

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References

    1. Cancer Invest. 1993;11(5):624-34 - PubMed
    1. Blood. 1993 Oct 1;82(7):1960-74 - PubMed
    1. EMBO J. 1993 Nov;12(11):4181-9 - PubMed
    1. J Exp Med. 1993 Nov 1;178(5):1577-86 - PubMed
    1. Int Immunol. 1993 Sep;5(9):1183-90 - PubMed

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