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. 1976 Jan;13(1):252-62.
doi: 10.1128/iai.13.1.252-262.1976.

Adaptation of an osmotically fragile L-form of Streptococcus pyogenes to physiological osmotic conditions and its ability to destroy human heart cells in tissue culture

O Leon, C Panos

Adaptation of an osmotically fragile L-form of Streptococcus pyogenes to physiological osmotic conditions and its ability to destroy human heart cells in tissue culture

O Leon et al. Infect Immun. 1976 Jan.

Abstract

An osmotically fragile L-form of Streptococcus pyogenes, type 12, was quickly rendered osmotically stable by decreasing the sodium chloride content of the growth medium and with the temporary use of oleic acid. The change from osmotic fragility to stability was accompanied by changes in cell yield, generation time, saturated/unsaturated fatty acid ratio of the membrane, and cytoplasmic protein composition. Finally, this resulting osmotically stable L-form survived and was capable of rapidly destroying Girardi human heart cells in tissue culture.

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References

    1. Proc Soc Exp Biol Med. 1950 Jul;74(3):552-5 - PubMed
    1. J Biol Chem. 1967 Jan 25;242(2):173-81 - PubMed
    1. J Biol Chem. 1951 Nov;193(1):265-75 - PubMed
    1. Lancet. 1968 Apr 20;1(7547):847-8 - PubMed
    1. Infect Immun. 1974 Oct;10(4):889-914 - PubMed

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