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. 1994;36(12):1200-4.

[The effect of plasmin-modified proteinase inhibitors on macroglobulin production by human blood mononuclear cells in culture]

[Article in Russian]
S G Zhabin, N A Zorin, M I Musatov
  • PMID: 7652933

[The effect of plasmin-modified proteinase inhibitors on macroglobulin production by human blood mononuclear cells in culture]

[Article in Russian]
S G Zhabin et al. Tsitologiia. 1994.

Abstract

A study was made of the influence of plasmin (PL) complexes with alpha 2-macroglobulin (MG) and alpha 2-antiplasmin on secretion of MG, pregnancy-associated alpha 2-glycoprotein (PAG), and pregnancy-associated plasma protein A (PAPP-A) by mononuclear cells (MC), obtained from human peripheral blood. It has been shown that incubation of the MG-PL complexes with MC resulted in the increase in concentrations of all these macroglobulins (MG, PAG, and PAPP-A) in supernatants of cultured MC. We revealed the same effects of AP-PL with regard to the secretion of PZP and PAPP-A. However, this complex was found to suppress MG production by cultured MC. The effects found were dose dependent and some of them differed greatly in men and women, resp.

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