Myosin aggregates as a requirement for contraction and a proposal to the mechanism of contraction of actomyosin systems
- PMID: 765324
- DOI: 10.1093/oxfordjournals.jbchem.a130980
Myosin aggregates as a requirement for contraction and a proposal to the mechanism of contraction of actomyosin systems
Abstract
Glycerinated fibers of rabbit psoas muscle showed no augmentation of tension development upon incubation with heavy meromyosin, irrespective of whether the fibers were of standard length, stretched, or extracted of their myosin content. The effect of heavy meromyosin was to suppress contraction. These observations are in disagreement with certain recent published reports (Oplatka et al., 1974) and do tend to support the current sliding filament theory of muscle contraction and the necessity of bipolar myosin filaments for contraction. A possible mechanism of contraction in protein systems, including tension generation in actomyosin fibers and superprecipitation, is described emphasizing the polarity of both myosin and actin filaments.
Similar articles
-
Tension development in skinned glycerinated rabbit psoas fiber segments irrigated with soluble myosin fragments.Biochim Biophys Acta. 1976 Jul 9;440(1):241-58. doi: 10.1016/0005-2728(76)90127-4. Biochim Biophys Acta. 1976. PMID: 132970
-
Extraction and functional reformation of thick filaments in chemically skinned molluscan catch muscle fibers.J Biochem. 1979 Feb;85(2):535-40. doi: 10.1093/oxfordjournals.jbchem.a132361. J Biochem. 1979. PMID: 422545
-
Tension development in stretched glycerinated muscle fibers and contraction of 'ghost' myofibrils induced by irrigation with heavy meromyosin.FEBS Lett. 1974 Sep 1;45(1):55-8. doi: 10.1016/0014-5793(74)80809-4. FEBS Lett. 1974. PMID: 4607160 No abstract available.
-
Molecular mechanism of contraction.Annu Rev Biophys Bioeng. 1972;1:159-90. doi: 10.1146/annurev.bb.01.060172.001111. Annu Rev Biophys Bioeng. 1972. PMID: 4265262 Review. No abstract available.
-
The interaction of actin and myosin as the basic reaction in muscular contraction.Fortschr Zool. 1978;25(1):III-VI, 1-71. Fortschr Zool. 1978. PMID: 147229 Review. No abstract available.
Cited by
-
Incorporation of microinjected biotin-labelled actin into nascent myofibrils of cardiac myocytes: an immunoelectron microscopic study.J Muscle Res Cell Motil. 1993 Jun;14(3):292-301. doi: 10.1007/BF00123094. J Muscle Res Cell Motil. 1993. PMID: 8360318
-
ATP-induced reconfiguration of the micro-viscoelasticity of cardiac and skeletal myosin solutions.Appl Phys Lett. 2024 Oct 21;125(17):173702. doi: 10.1063/5.0224003. Appl Phys Lett. 2024. PMID: 39444380 Free PMC article.
-
In situ reconstitution of myosin filaments within the myosin-extracted myofibril in cultured skeletal muscle cells.J Cell Biol. 1982 Feb;92(2):324-32. doi: 10.1083/jcb.92.2.324. J Cell Biol. 1982. PMID: 7199529 Free PMC article.
