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Case Reports
. 1993 Aug;129(2):175-7.
doi: 10.1111/j.1365-2133.1993.tb03523.x.

The anticonvulsant hypersensitivity syndrome

S E Handfield-Jones  1 , R E Jenkins, S J Whittaker, C P Besse, D H McGibbon
Affiliations
Case Reports

The anticonvulsant hypersensitivity syndrome

S E Handfield-Jones et al. Br J Dermatol. 1993 Aug.

Abstract

Anticonvulsants can cause a characteristic hypersensitivity reaction. This multisystem reaction typically presents as fever, mucocutaneous eruptions, lymphadenopathy and hepatitis. There is cross-reactivity between different anticonvulsants, which complicates subsequent therapy. We report three cases to illustrate both the typical features, and less common complications, of this under-recognized and life-threatening syndrome.

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