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Clinical Trial
. 1995 Sep;127(3):491-4.
doi: 10.1016/s0022-3476(95)70089-7.

Single- and multiple-dose-response relationships of beta-carotene in cystic fibrosis

D N Homnick  1 , C R Spillers, S R Cox, J H Cox, L A Yelton, M J DeLoof, L K Oliver, T V Ringer
Affiliations
Clinical Trial

Single- and multiple-dose-response relationships of beta-carotene in cystic fibrosis

D N Homnick et al. J Pediatr. 1995 Sep.

Abstract

Concentrations of carotenoids are low in patients with cystic fibrosis (CF) and are associated with essential fatty acid deficiency and increased markers of inflammation. We conducted single- and multiple-dose studies of beta-carotene supplementation in patients with CF. Dose-proportional increases in beta-carotene concentrations were found, although clearance was independent of dose. Large doses of beta-carotene were necessary to achieve normal plasma levels.

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