Pharmacologic treatment of delusions

Abstract

Delusions usually respond to antipsychotic medications. When delusions are present within certain diagnostic categories, however, pharmacotherapy other than or in addition to antipsychotic agents is indicated. Many delusional disorders have been found to respond to pimozide even after failing to respond to other antipsychotic agents. Delusions accompanied by affective symptomatology should be treated with both antipsychotic medications and antidepressants or mood stabilizers. When delusions are the result of a medical condition, treatment of the medical condition may lead to resolution of the delusion.