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Review
. 1976 Jan;3(1):69-78.
doi: 10.1093/nar/3.1.69.

DNA replication in eukaryotes: a model for the specific involvement of chromatin subunits

D R Hewish
Free PMC article
Review

DNA replication in eukaryotes: a model for the specific involvement of chromatin subunits

D R Hewish. Nucleic Acids Res. 1976 Jan.
Free PMC article

Abstract

A model is proposed whereby eukaryotic DNA replication is specifically directed by the 200 base pair repeat structure of the DNA-histone complex. The model proposes a mechanism for the sequential, bidirectional replication of DNA from initial origin points on the chromatin fibre and is consistent with the known properties of eukaryotic DNA replication. Several predictions can be made from the model which are amenable to testing.

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References

    1. Proc Natl Acad Sci U S A. 1975 Jul;72(7):2550-4 - PubMed
    1. Proc Natl Acad Sci U S A. 1975 Mar;72(3):1043-5 - PubMed
    1. Nature. 1975 May 15;255(5505):247-9 - PubMed
    1. Biochemistry. 1975 Jul;14(13):2915-20 - PubMed
    1. Nature. 1975 Jan 24;253(5489):245-9 - PubMed