Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995;68(4):220-4.
doi: 10.1111/j.1423-0410.1995.tb02576.x.

Evaluation of a combined HIV-1/2 and HTLV-I/II assay for screening blood donors

P Flanagan  1 , L McAlpine, S J Ramskill, A G Smith, R Eglin, J V Parry, P P Mortimer
Affiliations

Evaluation of a combined HIV-1/2 and HTLV-I/II assay for screening blood donors

P Flanagan et al. Vox Sang. 1995.

Abstract

A combined immunoassay for the simultaneous detection of antibodies to HIV-1/2 and HTLV-I/II (Bioelisa, Launch Diagnostics) has been evaluated to determine its suitability for routine use in blood screening. 84,222 donations were tested from 76,452 donors. One HIV- and 1 HTLV-1-positive donor were identified. The specificity was 99.7%, and the sensitivity for anti-HIV-1, anti-HIV-2, and anti-HTLV-1 on 173 positive sera was 100%; 2 of 25 anti-HTLV-II-positive sera were non-reactive. Although the specificity of the assay is not as high as that of HIV-1/2 kits currently in UK transfusion use, the information gained about donor HTLV antibody status makes the test an attractive alternative to them.

PubMed Disclaimer

LinkOut - more resources