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Clinical Trial
. 1976 Feb;15(1):17-23.
doi: 10.1093/rheumatology/15.1.17.

The effect of low doses of prednisolone compared with placebo on function and on the hypothalamic pituitary adrenal axis in patients with rheumatoid arthritis

M A Chamberlain, J Keenan
Clinical Trial

The effect of low doses of prednisolone compared with placebo on function and on the hypothalamic pituitary adrenal axis in patients with rheumatoid arthritis

M A Chamberlain et al. Rheumatol Rehabil. 1976 Feb.

Abstract

A double-blind trial of prednisolone in patients with rheumatoid arthritis using doses of zero, 3 mg and 5 mg is reported. Patients on a dose of 3 mg derived little sustained benefit but subjects on the higher dose showed some improvement which did not last more than two years. Mild suppression of the hypothalamo-pituitary-adrenal axis occurred in both steroid-treated groups.

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