Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Jun;14(6):436-9.
doi: 10.1007/BF01573954.

Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus

I Kojima  1 , Y R Cheng, V Mohan, A L Demain
Affiliations

Carbon source nutrition of rapamycin biosynthesis in Streptomyces hygroscopicus

I Kojima et al. J Ind Microbiol. 1995 Jun.

Abstract

Chemically-defined media were developed for rapamycin production by Streptomyces hygroscopicus. Thirty-five carbon sources were tested for their effect on production. Eight failed to support growth and seven appeared to repress or inhibit rapamycin formation. The best combination of two carbon sources were 2% fructose and 0.5% mannose. Acetate and propionate, which are known to contribute most of the carbon atoms of the lactone ring, were unsatisfactory for growth and/or rapamycin production.

PubMed Disclaimer

References

    1. Med Res Rev. 1994 Jan;14(1):1-22 - PubMed
    1. J Nat Prod. 1991 Jan-Feb;54(1):167-77 - PubMed
    1. J Antibiot (Tokyo). 1983 Apr;36(4):351-4 - PubMed
    1. J Antibiot (Tokyo). 1975 Oct;28(10):727-32 - PubMed
    1. J Antibiot (Tokyo). 1975 Oct;28(10):721-6 - PubMed

Publication types

MeSH terms

LinkOut - more resources