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. 1995 Jul;15(1):5-9.
doi: 10.1007/BF01570006.

Production of brefeldin-A

T G McCloud  1 , M P Burns, F D Majadly, G M Muschik, D A Miller, K K Poole, J M Roach, J T Ross, W B Lebherz 3rd
Affiliations

Production of brefeldin-A

T G McCloud et al. J Ind Microbiol. 1995 Jul.

Abstract

Fermentation conditions are described for the production of the antitumor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture by Eupenicillium brefeldianum, (B.Dodge) Stolk and Scott, ATCC 58665. An analytical hplc method was developed which allowed rapid quantitation of the compound during fermentation. A kilogram of brefeldin-A was isolated from a fermentation at the 6800-liter scale.

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