Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Jul;15(1):5-9.
doi: 10.1007/BF01570006.

Production of brefeldin-A

T G McCloud  1 , M P Burns, F D Majadly, G M Muschik, D A Miller, K K Poole, J M Roach, J T Ross, W B Lebherz 3rd
Affiliations

Production of brefeldin-A

T G McCloud et al. J Ind Microbiol. 1995 Jul.

Abstract

Fermentation conditions are described for the production of the antitumor antibiotic 7-(S)-brefeldin-A (brefeldin-A) in liquid culture by Eupenicillium brefeldianum, (B.Dodge) Stolk and Scott, ATCC 58665. An analytical hplc method was developed which allowed rapid quantitation of the compound during fermentation. A kilogram of brefeldin-A was isolated from a fermentation at the 6800-liter scale.

PubMed Disclaimer

References

    1. J Antibiot (Tokyo). 1993 Jul;46(7):1082-8 - PubMed
    1. Proc Soc Exp Biol Med. 1989 Mar;190(3):286-93 - PubMed
    1. J Antibiot (Tokyo). 1983 Jan;36(1):25-9 - PubMed
    1. Endocr Rev. 1990 May;11(2):354-85 - PubMed
    1. Folia Microbiol (Praha). 1962 Nov;7:353-7 - PubMed

MeSH terms