Comparing transcriptional initiation by RNA polymerases I and III
- PMID: 7662364
- DOI: 10.1016/0955-0674(95)80089-1
Comparing transcriptional initiation by RNA polymerases I and III
Abstract
We comment on the current understanding of transcriptional initiation by RNA polymerases I and III, and look for common modes of operation of these enzymes, emphasizing selected recent developments. These include definitive experiments on the constitution of the human RNA polymerase I transcription factor SL1/TIF-IB, the development of a genetic system for analyzing the function of RNA polymerase I in yeast, the elucidation of the structure of the human snRNA gene transcription factor SNAPc, and initial stages of mapping the protein-protein interactions involved in the assembly of transcriptional initiation complexes.
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