doi: 10.1038/nsb0594-293.
A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers
Affiliations
- PMID: 7664035
- DOI: 10.1038/nsb0594-293
Item in Clipboard
A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers
Nat Struct Biol.
1994 May.
Abstract
Coordinated variations in the sequence of the Rev-binding element of HIV-1, identified by in vitro genetic selections, have been used as distance and conformational constraints for molecular modelling. Three-dimensional models of the wild-type Rev-binding element and several, evolved RNA ligands (aptamers) have been constructed. These models demonstrate that non-Watson-Crick pairings open the major groove allowing access of an alpha-helical peptide from Rev, and explain why some selected RNA sequences can bind Rev more tightly than others.
Comment in
-
Challenging the predictors.Nat Struct Biol. 1994 May;1(5):265-6. doi: 10.1038/nsb0594-265. Nat Struct Biol. 1994. PMID: 7545069 No abstract available.
-
A slippery grip.Nat Struct Biol. 1994 May;1(5):267-9. doi: 10.1038/nsb0594-267. Nat Struct Biol. 1994. PMID: 7545070 No abstract available.
-
RNA origami.Nat Struct Biol. 1994 May;1(5):270-2. doi: 10.1038/nsb0594-270. Nat Struct Biol. 1994. PMID: 7545071 No abstract available.
Similar articles
-
Binding of an HIV Rev peptide to Rev responsive element RNA induces formation of purine-purine base pairs.Biochemistry. 1994 Mar 15;33(10):2741-7. doi: 10.1021/bi00176a001. Biochemistry. 1994. PMID: 8130185
-
Anti-peptide aptamers recognize amino acid sequence and bind a protein epitope.Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7475-80. doi: 10.1073/pnas.93.15.7475. Proc Natl Acad Sci U S A. 1996. PMID: 8755498 Free PMC article.
-
Interaction of HIV Rev peptides with the Rev response element RNA.Nucleic Acids Symp Ser. 1995;(33):46-8. Nucleic Acids Symp Ser. 1995. PMID: 8643394
-
Adaptive recognition in RNA complexes with peptides and protein modules.Curr Opin Struct Biol. 1999 Feb;9(1):74-87. doi: 10.1016/s0959-440x(99)80010-4. Curr Opin Struct Biol. 1999. PMID: 10047585 Review.
-
[RNA ligands for HIV proteins].Tanpakushitsu Kakusan Koso. 1995 Jul;40(10):1430-7. Tanpakushitsu Kakusan Koso. 1995. PMID: 7568944 Review. Japanese. No abstract available.
Cited by
-
Modeling active RNA structures using the intersection of conformational space: application to the lead-activated ribozyme.RNA. 1998 Jul;4(7):739-49. doi: 10.1017/s1355838298971266. RNA. 1998. PMID: 9671048 Free PMC article.
-
Assignment and modeling of the Rev Response Element RNA bound to a Rev peptide using 13C-heteronuclear NMR.J Biomol NMR. 1995 Dec;6(4):375-89. doi: 10.1007/BF00197637. J Biomol NMR. 1995. PMID: 8563466
-
Methylphosphonate mapping of phosphate contacts critical for RNA recognition by the human immunodeficiency virus tat and rev proteins.Nucleic Acids Res. 1994 Jul 11;22(13):2592-600. doi: 10.1093/nar/22.13.2592. Nucleic Acids Res. 1994. PMID: 8041622 Free PMC article.
-
HyPaLib: a database of RNAs and RNA structural elements defined by hybrid patterns.Nucleic Acids Res. 2001 Jan 1;29(1):196-8. doi: 10.1093/nar/29.1.196. Nucleic Acids Res. 2001. PMID: 11125089 Free PMC article.
-
RNA tertiary structure of the HIV RRE domain II containing non-Watson-Crick base pairs GG and GA: molecular modeling studies.Nucleic Acids Res. 1994 Sep 25;22(19):3966-76. doi: 10.1093/nar/22.19.3966. Nucleic Acids Res. 1994. PMID: 7937119 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources