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. 1994 May;1(5):293-300.
doi: 10.1038/nsb0594-293.

A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers

F Leclerc  1 , R Cedergren, A D Ellington
Affiliations

A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers

F Leclerc et al. Nat Struct Biol. 1994 May.

Abstract

Coordinated variations in the sequence of the Rev-binding element of HIV-1, identified by in vitro genetic selections, have been used as distance and conformational constraints for molecular modelling. Three-dimensional models of the wild-type Rev-binding element and several, evolved RNA ligands (aptamers) have been constructed. These models demonstrate that non-Watson-Crick pairings open the major groove allowing access of an alpha-helical peptide from Rev, and explain why some selected RNA sequences can bind Rev more tightly than others.

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Comment in

  • Challenging the predictors.
    [No authors listed] [No authors listed] Nat Struct Biol. 1994 May;1(5):265-6. doi: 10.1038/nsb0594-265. Nat Struct Biol. 1994. PMID: 7545069 No abstract available.
  • A slippery grip.
    Fedor MJ. Fedor MJ. Nat Struct Biol. 1994 May;1(5):267-9. doi: 10.1038/nsb0594-267. Nat Struct Biol. 1994. PMID: 7545070 No abstract available.
  • RNA origami.
    Williamson JR. Williamson JR. Nat Struct Biol. 1994 May;1(5):270-2. doi: 10.1038/nsb0594-270. Nat Struct Biol. 1994. PMID: 7545071 No abstract available.

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