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. 1994 Jun;1(6):399-409.
doi: 10.1038/nsb0694-399.

Elucidating the folding problem of helical peptides using empirical parameters

V Muñoz  1 , L Serrano
Affiliations

Elucidating the folding problem of helical peptides using empirical parameters

V Muñoz et al. Nat Struct Biol. 1994 Jun.

Abstract

Using an empirical analysis of experimental data we have estimated a set of energy contributions which accounts for the stability of isolated alpha-helices. With this database and an algorithm based on statistical mechanics, we describe the average helical behaviour in solution of 323 peptides and the helicity per residue of those peptides analyzed by nuclear magnetic resonance. Moreover the algorithm successfully detects the alpha-helical tendency, in solution, of a peptide corresponding to a beta-strand of ubiquitin.

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  • The nature of the alpha-helix.
    [No authors listed] [No authors listed] Nat Struct Biol. 1994 Jun;1(6):343-4. doi: 10.1038/nsb0694-343. Nat Struct Biol. 1994. PMID: 7664041 No abstract available.

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