Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1995 Jun;12(6):902-4.
doi: 10.1023/a:1016225423795.

Effect of corticosteroid binding globulin on the pharmacokinetics of prednisolone in rats

H C Ko  1 , R R Almon, W J Jusko
Affiliations

Effect of corticosteroid binding globulin on the pharmacokinetics of prednisolone in rats

H C Ko et al. Pharm Res. 1995 Jun.

Abstract

Purpose: The effect of exogenous corticosteroid binding globulin (CBG) on the pharmacokinetics of intravenous prednisolone was determined in rats to test the "free hormone hypothesis."

Methods: A dose of CBG to yield 95% binding with 1000 ng/ml of prednisolone in vitro in rat plasma or saline was administered before dosing 2 mg/kg of prednisolone hemisuccinate or methylprednisolone intravenously. Drug concentrations in plasma samples were assayed by HPLC.

Results: Single administration of CBG decreased apparent prednisolone clearance by 56% (155 to 66 ml/min/kg) and reduced apparent VSS by 35% (4.1 to 2.7 L/kg) (p < 0.001). Methylprednisolone pharmacokinetics, studied as a negative control because the drug does not bind to CBG, did not change.

Conclusions: The corticosteroid bound to CBG does not appear to be available for removal by clearance organs.

PubMed Disclaimer

References

    1. J Pharmacol Exp Ther. 1987 Jun;241(3):934-8 - PubMed
    1. J Pharm Sci. 1986 Aug;75(8):760-3 - PubMed
    1. Nature. 1970 Aug 15;227(5259):680-5 - PubMed
    1. Endocr Rev. 1989 Aug;10(3):232-74 - PubMed
    1. J Pharmacokinet Biopharm. 1990 Jun;18(3):189-208 - PubMed

Publication types

LinkOut - more resources