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. 1995 Aug 29;92(18):8259-63.
doi: 10.1073/pnas.92.18.8259.

Predicting coiled coils by use of pairwise residue correlations

B Berger  1 , D B Wilson, E Wolf, T Tonchev, M Milla, P S Kim
Affiliations

Predicting coiled coils by use of pairwise residue correlations

B Berger et al. Proc Natl Acad Sci U S A. .

Abstract

A method is presented that predicts coiled-coil domains in protein sequences by using pairwise residue correlations obtained from a (two-stranded) coiled-coil database of 58,217 amino acid residues. A program called PAIRCOIL implements this method and is significantly better than existing methods at distinguishing coiled coils from alpha-helices that are not coiled coils. The database of pairwise residue correlations suggests structural features that stabilize or destabilize coiled coils.

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