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Clinical Trial
. 1975 Dec;32(6):730-6.
doi: 10.1038/bjc.1975.284.

Chemotherapy of advanced breast cancer: a controlled randomized trial of cyclophosphamide versus a four-drug combination

R D Rubens, R K Knight, J L Hayward
Free PMC article
Clinical Trial

Chemotherapy of advanced breast cancer: a controlled randomized trial of cyclophosphamide versus a four-drug combination

R D Rubens et al. Br J Cancer. 1975 Dec.
Free PMC article

Abstract

Ninety-nine patients with advanced breast cancer were randomized to receive either cyclophosphamide continuously or a combination of cyclophosphamide, methotrexate, 5-fluorouracil and vinblastine given intermittently. The number and duration of objective responses were greater in patients receiving the combination but the differences between the two treatments did not achieve formal significance. The combination was logistically easier to manage and produced less toxicity.

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