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Comparative Study
. 1995 Sep;72(3):646-9.
doi: 10.1038/bjc.1995.388.

Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16

M J Arends  1 , A H Wyllie, C C Bird
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Free PMC article
Comparative Study

Human papillomavirus type 18 is associated with less apoptosis in fibroblast tumours than human papillomavirus type 16

M J Arends et al. Br J Cancer. 1995 Sep.
Free PMC article

Abstract

In human cervical neoplasia human papillomavirus (HPV) type 18 has a higher cancer/cervical intraepithelial neoplasia (CIN) prevalence ratio than HPV 16. Fibrosarcomas derived from rat fibroblasts transfected with HPV 16 or 18 genomes showed increased apoptosis compared with controls. However, HPV 18 was associated with significantly less apoptosis than HPV 16, affording one possible explanation for the more rapidly progressive cervical neoplasia associated with HPV 18.

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