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. 1995 Aug;10(4):466-71.
doi: 10.1038/ng0895-466.

Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice

E I Rugarli  1 , D A Adler, G Borsani, K Tsuchiya, B Franco, X Hauge, C Disteche, V Chapman, A Ballabio
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Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice

E I Rugarli et al. Nat Genet. 1995 Aug.

Abstract

We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.

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Comment in

  • Ecce Ohno!
    Ellis NA. Ellis NA. Nat Genet. 1995 Aug;10(4):373-5. doi: 10.1038/ng0895-373. Nat Genet. 1995. PMID: 7670482 No abstract available.
  • Breaking laws and obeying rules.
    Graves JA. Graves JA. Nat Genet. 1996 Feb;12(2):121-2. doi: 10.1038/ng0296-121a. Nat Genet. 1996. PMID: 8563745 No abstract available.

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