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Comparative Study
. 1993;26(1-2):233-8.

Serum levels of tumor necrosis factor in patients with American cutaneous leishmaniasis

M Castes  1 , D Trujillo, M E Rojas, C T Fernandez, L Araya, M Cabrera, J Blackwell, J Convit
Affiliations
  • PMID: 7670536
Comparative Study

Serum levels of tumor necrosis factor in patients with American cutaneous leishmaniasis

M Castes et al. Biol Res. 1993.

Abstract

The purpose of this study was to evaluate serum levels of TNF-alpha in patients with either of the three clinical forms of American cutaneous leishmaniasis. The 86 patients examined were classified as having either the localized (LCL: 22 patients), mucocutaneous (MCL: 45 patients), or the rare diffuse (DCL: 19 patients) form of the disease. Our results show a significant increase in the mean level of TNF-alpha in the three groups of patients when compared to controls. MCL patients produce significantly higher levels of TNF-alpha than DCL patients. The proportion of individuals positive for serum TNF-alpha was significantly higher in both MCL and DCL patients than in the controls. No significant differences were found in the level of TNF-alpha when compared between before and after cure of 12 patients with MCL. There were no significant correlations between the level of TNF-alpha and the skin test diameter. The results will be discussed in terms of the pathogenesis of the disease in its different clinical forms.

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