A case of severe ovarian hyperstimulation in a healthy oocyte donor

Abstract

Objective: To report an unexpected case of severe ovarian hyperstimulation syndrome (OHSS) and to compare E2 levels and number of follicles to other oocyte donors.

Setting: Private assisted reproduction technology center.

Patients: Healthy oocyte donors with normal menstrual cyclicity.

Interventions: Prophylactic and therapeutic use of human serum albumin infusions.

Main outcome measure: The clinical development of signs and symptoms of severe OHSS.

Results: More than 60% of other oocyte donors had higher E2 levels and 12% had higher number of follicles without associated OHSS.

Conclusion: The risk of developing severe OHSS cannot be predicted accurately to be low even in the absence of "risk factors."