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Clinical Trial
. 1978 Apr 8;1(8067):749-51.
doi: 10.1016/s0140-6736(78)90861-9.

Acid-phosphatase reaction in acute lymphoblastic leukaemia

D Catovsky, M Cherchi, M F Greaves, G Janossy, C Pain, H E Kay
Clinical Trial

Acid-phosphatase reaction in acute lymphoblastic leukaemia

D Catovsky et al. Lancet. .

Abstract

The diagnostic value of the acid-phosphatase reaction was assessed double-blind in 148 cases of acute lymphoblastic leukaemia (A.L.L.) classified by surface-membrane markers and entered into the M.R.C. U.K. A.L.L. trials. 90% of cases of T-A.L.L. showed a positive reaction in the majority of blast cells, while only 2% of common-A.L.L. and 10% of null-A.L.L. were positive. This cytochemical reaction distinguished the more aggressive form of A.L.L. any may aid the choice of therapy.

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