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. 1993 Jan;61(1):356-9.
doi: 10.1128/iai.61.1.356-359.1993.

Staphylococcal enterotoxin A gene (sea) expression is not affected by the accessory gene regulator (agr)

M T Tremaine  1 , D K Brockman, M J Betley
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Staphylococcal enterotoxin A gene (sea) expression is not affected by the accessory gene regulator (agr)

M T Tremaine et al. Infect Immun. 1993 Jan.

Abstract

The goal of this work was to determine whether staphylococcal enterotoxin type A gene (sea) expression is regulated by an accessory gene regulator (agr). The Tn551 insertionally inactivated agr allele of Staphylococcus aureus ISP546 was transferred to three Sea+ S. aureus strains. Each of the Agr- strains produced as much staphylococcal enterotoxin A (SEA) as its parent strain. These results suggest that sea expression is regulated differently from that of seb, sec, and sed, which previously have been shown to require a functional agr system for maximal expression.

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