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. 1993 Jan 1;90(1):312-6.
doi: 10.1073/pnas.90.1.312.

The multidrug resistance (mdr1) gene product functions as an ATP channel

E H Abraham  1 , A G Prat, L Gerweck, T Seneveratne, R J Arceci, R Kramer, G Guidotti, H F Cantiello
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The multidrug resistance (mdr1) gene product functions as an ATP channel

E H Abraham et al. Proc Natl Acad Sci U S A. .

Abstract

The multidrug resistance (mdr1) gene product, P-glycoprotein, is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increased levels of the P-glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane. Furthermore, measurements of whole-cell and single-channel currents with patch-clamp electrodes indicate that the P-glycoprotein serves as an ATP-conducting channel in the plasma membrane. These findings suggest an unusual role for the P-glycoprotein.

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References

    1. Biochemistry. 1989 Jan 24;28(2):866-73 - PubMed
    1. Int J Cancer. 1989 Feb 15;43(2):340-3 - PubMed
    1. Cancer Res. 1989 Jun 1;49(11):2988-93 - PubMed
    1. Mol Cell Biol. 1989 Mar;9(3):1346-50 - PubMed
    1. Science. 1989 Jun 30;244(4912):1558-64 - PubMed

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