Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Jan 15;90(2):755-9.
doi: 10.1073/pnas.90.2.755.

Ca2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6

J Egebjerg  1 , S F Heinemann
Affiliations

Ca2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6

J Egebjerg et al. Proc Natl Acad Sci U S A. .

Abstract

The Ca2+ permeability of the kainate selective glutamate receptor GluR6 depends on the editing of the RNA (or DNA). The unedited version of GluR6, GluR6Q, encodes a glutamine at position 621 (Q/R site) and exhibits a Ca2+/monovalent ion permeability ratio of 1.2, while the edited version of GluR6, GluR6R, encodes an arginine at position 621 and exhibits a permeability ratio of 0.47. Kainate activation of the GluR6 receptor results in currents that are modulated by extracellular calcium ions. Permeability ratios of other divalent ions indicate that the Q/R site is not the only determinant for divalent ion permeability. The level of editing of the receptor will determine the Ca2+ influx through the GluR6 receptor channels and, consequently, may modulate the synaptic activity.

PubMed Disclaimer

References

    1. Neuron. 1992 Jan;8(1):127-34 - PubMed
    1. Cell. 1991 Oct 4;67(1):11-9 - PubMed
    1. Neuron. 1992 Jan;8(1):189-98 - PubMed
    1. Neuron. 1992 Feb;8(2):257-65 - PubMed
    1. Neuron. 1992 Feb;8(2):267-74 - PubMed

Publication types

LinkOut - more resources