Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1993 Feb;25(1 Pt 1):669-72.

Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report

R Shapiro  1 , M L Jordan, V P Scantlebury, J J Fung, C Jensen, C Vivas, J McCauley, W D Irish, S Mitchell, A J Demetris, et al.
Affiliations
Clinical Trial

Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report

R Shapiro et al. Transplant Proc. 1993 Feb.

Abstract

FK 506 was used as a primary immunosuppressive agent in 125 cases of renal transplantation in a randomized trial comparing FK 506/prednisone with FK 506/azathioprine/prednisone. With a mean follow-up of 5.5 +/- 2.5 months, there has been a 6-month actuarial patient survival of 99% and graft survival of 88%. There is no difference thus far between the two-drug and three-drug groups, although there may be less rejection and diabetes in the three-drug group. These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.

PubMed Disclaimer

Figures

Fig 1
Fig 1
Actuarial patient survival: FK 506/prednisone vs FK 506/azathioprine/prednisone.
Fig 2
Fig 2
Actuarial graft survival: FK 506/prednisone vs FK 506/azathioprine/prednisone.
See this image and copyright information in PMC

References

    1. Starzl TE, Fung JJ, Jordan M, et al. JAMA. 1990;264:63. - PMC - PubMed
    1. Shapiro R, Jordan M, Fung JJ, et al. Transplant Proc. 1991;23:920. - PMC - PubMed
    1. Shapiro R, Jordan ML, Scantlebury V, et al. Transplant Proc. 1991;23:3065. - PMC - PubMed

LinkOut - more resources