doi: 10.1006/bbrc.1993.1147.
The chimeric receptor between interleukin-2 receptor beta chain and interleukin-4 receptor transduces interleukin-2 signal
Affiliations
- PMID: 7679903
- DOI: 10.1006/bbrc.1993.1147
Item in Clipboard
The chimeric receptor between interleukin-2 receptor beta chain and interleukin-4 receptor transduces interleukin-2 signal
Biochem Biophys Res Commun.
.
Abstract
Transfectants expressing the chimeric receptor which has human interleukin-4 receptor (hIL-4R) in the extracellular domain and human interleukin-2 receptor beta chain (hIL-2R beta) in the cytoplasmic domain showed continuous growth in response to human interleukin-4 (hIL-4), whereas transfectants expressing hIL-4R responded only transiently to hIL-4. The pattern of tyrosine phosphorylation induced by hIL-4 in transfectants expressing the chimeric receptor was very similar to that in transfectants expressing hIL-2R beta, but different from that in transfectants expressing hIL-4R, indicating that the chimeric receptor transduces the interleukin-2 like growth signal by hIL-4.
Similar articles
-
A synthetic peptide corresponding to a critical intracellular signaling region of the human IL-4 receptor inhibits IL-4-induced proliferation.Cell Immunol. 1995 Jul;163(2):254-9. doi: 10.1006/cimm.1995.1124. Cell Immunol. 1995. PMID: 7606796
-
Characterization of critical residues in the cytoplasmic domain of the human interleukin-5 receptor alpha chain required for growth signal transduction.Eur J Immunol. 1995 Jul;25(7):1857-64. doi: 10.1002/eji.1830250710. Eur J Immunol. 1995. PMID: 7542592
-
The cell dissociation and motility triggered by scatter factor/hepatocyte growth factor are mediated through the cytoplasmic domain of the c-Met receptor.Oncogene. 1993 Sep;8(9):2381-90. Oncogene. 1993. PMID: 7689722
-
The interleukin-4 receptor: signal transduction by a hematopoietin receptor.J Leukoc Biol. 1994 Feb;55(2):272-9. doi: 10.1002/jlb.55.2.272. J Leukoc Biol. 1994. PMID: 7507973 Review.
-
The interleukin-4 receptor: structure, function, and signal transduction.Chem Immunol. 1992;51:107-34. Chem Immunol. 1992. PMID: 1567539 Review. No abstract available.
Cited by
-
Two distinct functional sites of human interleukin 4 are identified by variants impaired in either receptor binding or receptor activation.EMBO J. 1993 Dec 15;12(13):5121-9. doi: 10.1002/j.1460-2075.1993.tb06207.x. EMBO J. 1993. PMID: 8262056 Free PMC article.
-
Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4.J Biol Chem. 2010 Aug 13;285(33):25538-44. doi: 10.1074/jbc.M110.127951. Epub 2010 Jun 18. J Biol Chem. 2010. PMID: 20562098 Free PMC article.
-
The common γ-chain cytokine receptor: tricks-and-treats for T cells.Cell Mol Life Sci. 2016 Jan;73(2):253-69. doi: 10.1007/s00018-015-2062-4. Epub 2015 Oct 14. Cell Mol Life Sci. 2016. PMID: 26468051 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
