Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1993 Feb 26;259(5099):1318-20.
doi: 10.1126/science.7680492.

The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis

T Miyata  1 , J Takeda, Y Iida, N Yamada, N Inoue, M Takahashi, K Maeda, T Kitani, T Kinoshita
Affiliations

The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis

T Miyata et al. Science. .

Abstract

The glycosylphosphatidylinositol (GPI) anchor is a membrane attachment structure of many proteins and occurs in a wide variety of eukaryotes from yeasts to mammals. The structure of the core of the GPI anchor is conserved in protozoa and mammals and so is its biosynthetic pathway. A complementary DNA encoding a human protein termed PIG-A (phosphatidylinositol glycan-class A) was cloned. PIG-A was necessary for synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.

PubMed Disclaimer

Publication types

MeSH terms

Associated data

LinkOut - more resources