Review
doi: 10.1016/0166-2236(93)90020-m.
Agrin and the molecular choreography of synapse formation
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- PMID: 7680503
- DOI: 10.1016/0166-2236(93)90020-m
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Review
Agrin and the molecular choreography of synapse formation
Trends Neurosci.
1993 Feb.
Abstract
High concentrations of neurotransmitter receptors characterize neuromuscular junctions as well as neuron-neuron synapses in the brain and periphery. Synaptic function is critically dependent upon this marshalling of neurotransmitter receptors to the post-synaptic membrane. This review discusses agrin's role in orchestrating the molecular topography of the post-synaptic apparatus at nerve-muscle synapses and the emerging evidence suggesting a role for agrin in synaptogenesis in the brain.
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