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Review
. 1993 Feb;16(2):72-6.
doi: 10.1016/0166-2236(93)90020-m.

Agrin and the molecular choreography of synapse formation

M A Nastuk  1 , J R Fallon
Affiliations
Review

Agrin and the molecular choreography of synapse formation

M A Nastuk et al. Trends Neurosci. 1993 Feb.

Abstract

High concentrations of neurotransmitter receptors characterize neuromuscular junctions as well as neuron-neuron synapses in the brain and periphery. Synaptic function is critically dependent upon this marshalling of neurotransmitter receptors to the post-synaptic membrane. This review discusses agrin's role in orchestrating the molecular topography of the post-synaptic apparatus at nerve-muscle synapses and the emerging evidence suggesting a role for agrin in synaptogenesis in the brain.

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