Comparative Study
doi: 10.1038/362127a0.
Primary structure and functional expression of a mouse inward rectifier potassium channel
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- PMID: 7680768
- DOI: 10.1038/362127a0
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Comparative Study
Primary structure and functional expression of a mouse inward rectifier potassium channel
Nature.
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Abstract
A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.
Comment in
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Potassium channels. Advent of a new family.Nature. 1993 Mar 11;362(6416):107-8. doi: 10.1038/362107a0. Nature. 1993. PMID: 8450880 No abstract available.
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