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Comparative Study
. 1993 Mar 11;362(6416):127-33.
doi: 10.1038/362127a0.

Primary structure and functional expression of a mouse inward rectifier potassium channel

Y Kubo  1 , T J Baldwin, Y N Jan, L Y Jan
Affiliations
Comparative Study

Primary structure and functional expression of a mouse inward rectifier potassium channel

Y Kubo et al. Nature. .

Abstract

A complementary DNA encoding an inward rectifier K+ channel (IRK1) was isolated from a mouse macrophage cell line by expression cloning. This channel conducts inward K+ current below the K+ equilibrium potential but passes little outward K+ current. The IRK1 channel contains only two putative transmembrane segments per subunit and corresponds to the inner core structure of voltage-gated K+ channels. The IRK1 channel and an ATP-regulated K+ channel show extensive sequence similarity and constitute a new superfamily.

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