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Clinical Trial
. 1993 Feb;26(2):111-6.
doi: 10.1016/0167-8140(93)90091-l.

Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases

C Haie-Meder  1 , B Pellae-Cosset, A Laplanche, J L Lagrange, C Tuchais, C Nogues, R Arriagada
Affiliations
Clinical Trial

Results of a randomized clinical trial comparing two radiation schedules in the palliative treatment of brain metastases

C Haie-Meder et al. Radiother Oncol. 1993 Feb.

Abstract

In 216 patients with brain metastases two schedules of brain irradiation were compared in a randomized trial: one course of 18 Gy/3 fractions/3 days versus the same fractionation followed by a second course of radiotherapy with a one-month time interval. The second course was identical to the first one or delivered 25 Gy/10 fractions/14 days. No difference in overall survival, nor in the neurologic response or in the incidence of complications was demonstrated. Two clinical factors appeared to be prognostic of the overall survival: the presence of multiple brain metastases and the presence of extracerebral metastases.

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