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. 1993 Mar 31;191(3):1288-93.
doi: 10.1006/bbrc.1993.1357.

Characterization and acute phase modulation of canine apolipoprotein H (beta 2-glycoprotein I)

G C Sellar  1 , J Keane, H Mehdi, M E Peeples, N Browne, A S Whitehead
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Characterization and acute phase modulation of canine apolipoprotein H (beta 2-glycoprotein I)

G C Sellar et al. Biochem Biophys Res Commun. .

Abstract

Apolipoprotein H (ApoH) is a 50 kDa glycoprotein capable of binding to negatively charged phospholipids and is a probable inhibitor of the blood coagulation pathway, platelet aggregation, and platelet prothrombinase activity, as well as being involved in autoimmune disease. We have cloned and sequenced a full length ApoH cDNA clone from a beagle dog liver library. Its derived amino acid sequence shows high cross-species similarity to ApoH from other mammals. Canine ApoH mRNA expression is down regulated during an experimentally induced inflammatory response establishing that it is a negative acute phase reactant.

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