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Case Reports
. 1993 Apr;33(4):407-11.
doi: 10.1002/ana.410330415.

Successful outcome of progressive multifocal leukoencephalopathy with cytarabine and interferon

M J Steiger  1 , G Tarnesby, S Gabe, J McLaughlin, A H Schapira
Affiliations
Case Reports

Successful outcome of progressive multifocal leukoencephalopathy with cytarabine and interferon

M J Steiger et al. Ann Neurol. 1993 Apr.

Abstract

The prognosis of patients with progressive multifocal leukoencephalopathy is poor, with few patients showing remission or surviving. We describe a 37-year-old man who developed progressive multifocal leukoencephalopathy in association with sarcoidosis. Despite treatment with cytarabine and acyclovir, he continued to deteriorate. Shortly following the addition of interferon alfa, he made a dramatic improvement, regaining full functional independence. The use of interferon alfa in addition to cytarabine in such patients offers a new therapeutic approach worthy of further trial.

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